Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01530-0002-0000-3 |
Chemical Name: | 5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) |
CASRN: | 2608-48-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 073716_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) | 2.6 | 200 | 4 | 0.020 | 2.0 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
3.5 | 200 | 5 | 0.025 | 1.5 | 1 | 0.005 | 0.5 | 4 | 0.020 | 1.0 | 0 | 0.000 | 0.0 | ||
8.7 | 200 | 13 | 0.065 | 4.0 | 6 | 0.030 | 2.5 | 7 | 0.035 | 2.0 | 0 | 0.000 | 0.0 | ||
17.5 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 29 | 0.145 | 13.0 | 17 | 0.085 | 7.5 | 12 | 0.060 | 6.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 14 | 0.560 | 40.0 | 6 | 0.240 | 20.0 | 8 | 0.320 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.701 | 0.798 | 2.233 | ||||||||||||
Probability: | 0.045 | 0.212 | 0.013 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | 5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) | 35.2 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 |
88 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
175.9 | 200 | 6 | 0.030 | 3.0 | 2 | 0.010 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
262.5 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 29 | 0.145 | 12.5 | 11 | 0.055 | 5.0 | 17 | 0.085 | 7.5 | 1 | 0.005 | 0.5 |
Cyclophosphamide | 37.5 | 25 | 19 | 0.760 | 52.0 | 6 | 0.240 | 16.0 | 13 | 0.520 | 40.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.756 | 1.217 | 0.404 | ||||||||||||
Probability: | 0.225 | 0.112 | 0.343 |