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Study Information
Study Attribute Value
CEBS Accession Number: 002-01530-0002-0000-3
Chemical Name: 5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD)
CASRN: 2608-48-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 073716_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/17/1985    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: 5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) 
2.6       
 200 4 0.020 2.0 3 0.015 1.5 1 0.005 0.5 0 0.000 0.0 
3.5       
 200 5 0.025 1.5 1 0.005 0.5 4 0.020 1.0 0 0.000 0.0 
8.7       
 200 13 0.065 4.0 6 0.030 2.5 7 0.035 2.0 0 0.000 0.0 
17.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 29 0.145 13.0 17 0.085 7.5 12 0.060 6.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 14 0.560 40.0 6 0.240 20.0 8 0.320 24.0 0 0.000 0.0
Trend: 1.701 0.798 2.233  
Probability: 0.045 0.212 0.013  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/19/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) 
35.2       
 200 4 0.020 2.0 1 0.005 0.5 2 0.010 1.0 1 0.005 0.5 
88         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
175.9       
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
262.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 29 0.145 12.5 11 0.055 5.0 17 0.085 7.5 1 0.005 0.5
Cyclophosphamide 
37.5       
 25 19 0.760 52.0 6 0.240 16.0 13 0.520 40.0 0 0.000 0.0
Trend: 0.756 1.217 0.404  
Probability: 0.225 0.112 0.343