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Study Information
Study Attribute Value
CEBS Accession Number: 002-01534-0001-0000-6
Chemical Name: 5-Aminosalicylic acid
CASRN: 89-57-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 040238_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/10/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 402 0.387 8.04 26.0 0.000
5-Aminosalicylic acid 
0         
 50 1044 338 0.324 6.76 26.0 -16.323
Test Chemical 5-Aminosalicylic acid 
28         
 50 1045 389 0.372 7.78 26.0 -3.789 
93         
 50 1045 340 0.325 6.80 26.0 -15.908 
280         
 50 1044 418 0.400 8.36 26.0 3.482
Positive Control Mitomycin-C 
 0.001     
 50 1052 571 0.543 11.42 26.0 40.285
Mitomycin-C 
 0.004     
 10 207 227 1.097 22.70 26.0 183.429
Trend: -0.121        
Probability: 0.548        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/10/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 389 0.372 7.78 26.0 0.000
5-Aminosalicylic acid 
0         
 50 1052 412 0.392 8.24 26.0 5.309
Test Chemical 5-Aminosalicylic acid 
28         
 50 1044 394 0.377 7.88 26.0 1.479 
93         
 50 1049 382 0.364 7.64 26.0 -2.080 
280         
 50 1046 383 0.366 7.66 26.0 -1.542
Positive Control Cyclophosphamide 
 0.125     
 50 1049 504 0.480 10.08 26.0 29.192
Cyclophosphamide 
 0.5       
 10 209 308 1.474 30.80 26.0 296.266
Trend: -0.366        
Probability: 0.643