Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01534-0001-0000-6 |
Chemical Name: | 5-Aminosalicylic acid |
CASRN: | 89-57-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 040238_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1039 | 402 | 0.387 | 8.04 | 26.0 | 0.000 |
5-Aminosalicylic acid | 0 | 50 | 1044 | 338 | 0.324 | 6.76 | 26.0 | -16.323 | |
Test Chemical | 5-Aminosalicylic acid | 28 | 50 | 1045 | 389 | 0.372 | 7.78 | 26.0 | -3.789 |
93 | 50 | 1045 | 340 | 0.325 | 6.80 | 26.0 | -15.908 | ||
280 | 50 | 1044 | 418 | 0.400 | 8.36 | 26.0 | 3.482 | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1052 | 571 | 0.543 | 11.42 | 26.0 | 40.285 |
Mitomycin-C | 0.004 | 10 | 207 | 227 | 1.097 | 22.70 | 26.0 | 183.429 | |
Trend: | -0.121 | ||||||||
Probability: | 0.548 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1046 | 389 | 0.372 | 7.78 | 26.0 | 0.000 |
5-Aminosalicylic acid | 0 | 50 | 1052 | 412 | 0.392 | 8.24 | 26.0 | 5.309 | |
Test Chemical | 5-Aminosalicylic acid | 28 | 50 | 1044 | 394 | 0.377 | 7.88 | 26.0 | 1.479 |
93 | 50 | 1049 | 382 | 0.364 | 7.64 | 26.0 | -2.080 | ||
280 | 50 | 1046 | 383 | 0.366 | 7.66 | 26.0 | -1.542 | ||
Positive Control | Cyclophosphamide | 0.125 | 50 | 1049 | 504 | 0.480 | 10.08 | 26.0 | 29.192 |
Cyclophosphamide | 0.5 | 10 | 209 | 308 | 1.474 | 30.80 | 26.0 | 296.266 | |
Trend: | -0.366 | ||||||||
Probability: | 0.643 |