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Study Information
Study Attribute Value
CEBS Accession Number: 002-01538-0001-0000-0
Chemical Name: 5-Chloro-o-toluidine
CASRN: 95-79-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 428912_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/19/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 430 0.411 8.60 26.0 0.000
Test Chemical 5-Chloro-o-toluidine 
1.6       
 50 1044 456 0.437 9.12 26.0 6.250 
5         
 50 1047 422 0.403 8.44 26.0 -1.954 
16         
 50 1049 493 0.470 9.86 26.0 14.323
Positive Control Mitomycin-C 
 0.005     
 25 522 599 1.148 23.96 26.0 179.138
Trend: 1.586        
Probability: 0.056        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/19/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 475 0.453 9.50 26.0 0.000
Test Chemical 5-Chloro-o-toluidine 
1.6       
 50 1046 424 0.405 8.48 26.0 -10.566 
5         
 50 1046 381 0.364 7.62 26.0 -19.636 
16         
 50 1047 441 0.421 8.82 26.0 -7.069
Positive Control Cyclophosphamide 
1         
 50 1046 888 0.849 17.76 26.0 87.305
Trend: -1.540        
Probability: 0.938