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Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01542-0001-0000-5 |
Chemical Name: | 5-Methoxypsoralen |
CASRN: | 484-20-8 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 197424_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
No Activation | 2 | Positive |
No Activation | 3 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL |
Number Cells Examined |
Number Chromosomes Examined |
Total Number SCEs |
SCE / Chromosome |
SCE / Cell |
Hours in BRDU |
% Increase Over Solvent Control |
||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 |
50 | 1042 | 389 | 0.373 | 7.78 | 26.0 | 0.000 |
Test Chemical | 5-Methoxypsoralen | 16 |
50 | 1026 | 635 | 0.619 | 12.70 | 26.0 | 65.785 |
50 |
50 | 1032 | 619 | 0.600 | 12.38 | 26.0 | 60.668 | ||
160 |
50 | 1028 | 645 | 0.627 | 12.90 | 26.0 | 68.068 | ||
500 |
50 | 1037 | 656 | 0.633 | 13.12 | 26.0 | 69.451 | ||
Positive Control | Mitomycin-C | 0.0E-4 |
50 | 1022 | 525 | 0.514 | 10.50 | 26.0 | 37.603 |
Mitomycin-C | 0.005 |
10 | 211 | 341 | 1.616 | 34.10 | 26.0 | 332.902 | |
Trend: | 7.133 | ||||||||
Probability: | 0.000 |
Dose µg/mL |
Number Cells Examined |
Number Chromosomes Examined |
Total Number SCEs |
SCE / Chromosome |
SCE / Cell |
Hours in BRDU |
% Increase Over Solvent Control |
||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 |
50 | 1039 | 416 | 0.400 | 8.32 | 26.0 | 0.000 |
Test Chemical | 5-Methoxypsoralen | 16 |
50 | 1044 | 708 | 0.678 | 14.16 | 26.0 | 69.377 |
50 |
50 | 1045 | 624 | 0.597 | 12.48 | 26.0 | 49.139 | ||
160 |
50 | 1042 | 624 | 0.599 | 12.48 | 26.0 | 49.568 | ||
500 |
50 | 1048 | 648 | 0.618 | 12.96 | 26.0 | 54.432 | ||
Positive Control | Mitomycin-C | 0.0625 |
10 | 210 | 620 | 2.952 | 62.00 | 26.0 | 637.386 |
Mitomycin-C | 0.25 |
10 | 208 | 800 | 3.846 | 80.00 | 26.0 | 860.614 | |
Trend: | 4.768 | ||||||||
Probability: | 0.000 |
Dose µg/mL |
Number Cells Examined |
Number Chromosomes Examined |
Total Number SCEs |
SCE / Chromosome |
SCE / Cell |
Hours in BRDU |
% Increase Over Solvent Control |
||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 |
50 | 1047 | 367 | 0.351 | 7.34 | 26.0 | 0.000 |
Test Chemical | 5-Methoxypsoralen | 16 |
50 | 1025 | 621 | 0.606 | 12.42 | 26.0 | 72.842 |
50 |
50 | 1033 | 570 | 0.552 | 11.40 | 26.0 | 57.418 | ||
160 |
50 | 1039 | 609 | 0.586 | 12.18 | 26.0 | 67.218 | ||
500 |
50 | 1043 | 599 | 0.574 | 11.98 | 26.0 | 63.841 | ||
Positive Control | Mitomycin-C | 0.0E-4 |
50 | 1035 | 583 | 0.563 | 11.66 | 26.0 | 60.697 |
Mitomycin-C | 0.005 |
10 | 209 | 292 | 1.397 | 29.20 | 26.0 | 298.582 | |
Trend: | 6.019 | ||||||||
Probability: | 0.000 |
Dose µg/mL |
Number Cells Examined |
Number Chromosomes Examined |
Total Number SCEs |
SCE / Chromosome |
SCE / Cell |
Hours in BRDU |
% Increase Over Solvent Control |
||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 |
50 | 1047 | 408 | 0.390 | 8.16 | 26.0 | 0.000 |
Test Chemical | 5-Methoxypsoralen | 160 |
50 | 1038 | 504 | 0.486 | 10.08 | 26.0 | 24.600 |
500 |
50 | 1029 | 608 | 0.591 | 12.16 | 26.0 | 51.626 | ||
1600 |
50 | 1040 | 624 | 0.600 | 12.48 | 26.0 | 53.971 | ||
2500 |
50 | 1036 | 611 | 0.590 | 12.22 | 26.0 | 51.345 | ||
Positive Control | Cyclophosphamide | 0.15 |
50 | 1024 | 535 | 0.522 | 10.70 | 26.0 | 34.073 |
Cyclophosphamide | 0.6 |
10 | 206 | 179 | 0.869 | 17.90 | 26.0 | 122.983 | |
Trend: | 7.469 | ||||||||
Probability: | 0.000 |