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Study Information
Study Attribute Value
CEBS Accession Number: 002-01542-0005-0000-9
Chemical Name: 5-Methoxypsoralen
CASRN: 484-20-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 653449_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/23/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 1.50 ± 0.63 0.1573
Test Chemical 5-Methoxypsoralen 
450         
 8 3.25 ± 1.46 0.0058
  
900         
 8 8.75 ± 1.64 0.0000
  
1800         
 8 6.75 ± 2.14 0.0000
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 11/05/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 4.25 ± 1.83 0.0001
  
200         
 8 8.25 ± 1.87 0.0000
Test Chemical 5-Methoxypsoralen 
450         
 8 1.25 ± 0.53 0.0506
  
900         
 8 3.00 ± 0.93 0.0010
  
1800         
 8 4.75 ± 1.69 0.0000
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed