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Study Information
Study Attribute Value
CEBS Accession Number: 002-01546-0002-0000-0
Chemical Name: 5-Nitro-o-anisidine
CASRN: 99-59-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 509998_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/04/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 5-Nitro-o-anisidine 
160         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
300         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
500         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 37 0.185 18.0 17 0.085 8.5 20 0.100 10.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 28 0.560 38.0 11 0.220 18.0 17 0.340 26.0 0 0.000 0.0
Trend: -0.306 0.000 -0.306  
Probability: 0.620 0.000 0.620  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/04/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 5-Nitro-o-anisidine 
1000         
 200 10 0.050 5.0 2 0.010 1.0 8 0.040 4.0 0 0.000 0.0 
1600         
 200 8 0.040 4.0 1 0.005 0.5 7 0.035 3.5 0 0.000 0.0 
4000         
 200 6 0.030 3.0 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 44 0.220 21.0 10 0.050 5.0 34 0.170 16.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 30 0.600 44.0 11 0.220 20.0 19 0.380 34.0 0 0.000 0.0
Trend: 0.826 1.564 0.074  
Probability: 0.204 0.059 0.471