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Study Information
Study Attribute Value
CEBS Accession Number: 002-01548-0001-0000-1
Chemical Name: 5-Nitroacenaphthene
CASRN: 602-87-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 864313_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/16/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 326 0.312 6.52 25.5 0.000
Test Chemical 5-Nitroacenaphthene 
1         
 50 1045 380 0.364 7.60 25.5 16.676 
3.3       
 50 1048 435 0.415 8.70 25.5 33.181 
10         
 50 1049 502 0.479 10.04 25.5 53.547 
33.3       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 587 0.560 11.74 25.5 79.546
Mitomycin-C 
 0.01      
 5 104 192 1.846 38.40 25.5 492.355
Trend: 6.374        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/19/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 525 153 0.291 6.12 25.2 0.000
Test Chemical 5-Nitroacenaphthene 
7.5       
 25 524 258 0.492 10.32 25.2 68.949 
10         
 25 522 333 0.638 13.32 25.2 118.898 
15         
 25 520 391 0.752 15.64 25.2 158.013 
20.1       
 0 0 0 0.000 0.00 25.2 N/A
Positive Control Mitomycin-C 
 0.001     
 25 524 321 0.613 12.84 25.2 110.204
Mitomycin-C 
 0.01      
 5 105 237 2.257 47.40 25.2 674.510
Trend: 10.511        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/14/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 304 0.291 6.08 25.5 0.000
Test Chemical 5-Nitroacenaphthene 
3.3       
 50 1049 798 0.761 15.96 25.5 161.749 
10         
 50 1047 730 0.697 14.60 25.5 139.902 
33.3       
 50 1044 1197 1.147 23.94 25.5 294.504 
100         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1046 526 0.503 10.52 25.5 73.026
Cyclophosphamide 
2         
 5 104 153 1.471 30.60 25.5 406.193
Trend: 21.363        
Probability: 0.000