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Study Information
Study Attribute Value
CEBS Accession Number: 002-01548-0002-0000-2
Chemical Name: 5-Nitroacenaphthene
CASRN: 602-87-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 864313_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 06/02/1987    Harvest Time: 20.2 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: 5-Nitroacenaphthene 
25         
 200 13 0.065 5.0 1 0.005 0.5 12 0.060 5.0 0 0.000 0.0 
75         
 200 9 0.045 3.5 0 0.000 0.0 9 0.045 3.5 0 0.000 0.0 
100         
 200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 49 0.245 20.0 23 0.115 10.5 26 0.130 11.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 21 0.840 56.0 10 0.400 24.0 11 0.440 40.0 0 0.000 0.0
Trend: 0.830 -0.449 0.916  
Probability: 0.203 0.673 0.180  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/02/1987    Harvest Time: 20.2 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 8 0.040 2.5 1 0.005 0.5 7 0.035 2.0 0 0.000 0.0
Test Chemical: 5-Nitroacenaphthene 
25         
 200 14 0.070 6.5 2 0.010 1.0 12 0.060 5.5 0 0.000 0.0 
75         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
100         
 200 11 0.055 5.0 1 0.005 0.5 10 0.050 4.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 24 0.120 11.0 4 0.020 2.0 20 0.100 9.5 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 13 0.520 44.0 2 0.080 8.0 11 0.440 36.0 0 0.000 0.0
Trend: 0.099 -0.240 0.212  
Probability: 0.461 0.595 0.416  


Trial #:2   Activation: No Activation    Date: 12/08/1987    Harvest Time: 20.2 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 5-Nitroacenaphthene 
25         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
50         
 200 6 0.030 2.5 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
75         
 200 4 0.020 1.5 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
100         
 200 8 0.040 3.5 4 0.020 1.5 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 64 0.320 24.0 32 0.160 14.0 32 0.160 13.5 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 12 0.480 36.0 7 0.280 28.0 5 0.200 8.0 0 0.000 0.0
Trend: 2.077 1.760 1.407  
Probability: 0.019 0.039 0.080