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Study Information
Study Attribute Value
CEBS Accession Number: 002-01554-0001-0000-8
Chemical Name: 6-Methoxy-2-benzothiazolamine
CASRN: 1747-60-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 773945_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/01/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 411 0.392 8.22 26.5 0.000
Test Chemical 6-Methoxy-2-benzothiazolamine 
1.6       
 50 1051 462 0.440 9.24 26.5 12.088 
5         
 50 1047 468 0.447 9.36 26.5 13.977 
16         
 50 1049 464 0.442 9.28 26.5 12.788 
50         
 50 1047 616 0.588 12.32 26.5 50.021 
160         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 524 0.500 10.48 26.5 27.494
Mitomycin-C 
 0.005     
 10 210 320 1.524 32.00 26.5 288.553
Trend: 5.943        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/01/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 449 0.428 8.98 26.0 0.000
Test Chemical 6-Methoxy-2-benzothiazolamine 
5         
 50 1050 830 0.790 16.60 26.0 84.679 
16         
 50 1051 1050 0.999 21.00 26.0 133.408 
50         
 10 210 310 1.476 31.00 26.0 244.883 
160         
 10 210 386 1.838 38.60 26.0 329.435 
500         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.1       
 50 1049 579 0.552 11.58 26.0 28.953
Cyclophosphamide 
 0.6       
 10 210 239 1.138 23.90 26.0 165.894
Trend: 24.027        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/12/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 444 0.423 8.88 26.0 0.000
Test Chemical 6-Methoxy-2-benzothiazolamine 
30         
 10 210 346 1.648 34.60 26.0 289.640 
50         
 10 210 361 1.719 36.10 26.0 306.532 
100         
 10 210 413 1.967 41.30 26.0 365.090 
160         
 10 210 403 1.919 40.30 26.0 353.829
Positive Control Cyclophosphamide 
 0.1       
 50 1050 553 0.527 11.06 26.0 24.550
Cyclophosphamide 
 0.6       
 10 210 228 1.086 22.80 26.0 156.757
Trend: 26.931        
Probability: 0.000