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Study Information
Study Attribute Value
CEBS Accession Number: 002-01554-0002-0000-9
Chemical Name: 6-Methoxy-2-benzothiazolamine
CASRN: 1747-60-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 773945_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 11/12/1986    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: 6-Methoxy-2-benzothiazolamine 
160         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
300         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
500         
 200 31 0.155 5.0 1 0.005 0.5 20 0.100 4.5 10 0.050 1.0
Positive Control: Mitomycin-C 
 0.0625    
 200 35 0.175 15.5 14 0.070 6.5 21 0.105 10.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 20 0.400 32.0 15 0.300 26.0 5 0.100 8.0 0 0.000 0.0
Trend: 3.265 -0.032 3.587  
Probability: 0.001 0.513 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/12/1986    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 6-Methoxy-2-benzothiazolamine 
100         
 200 51 0.255 12.5 9 0.045 4.0 32 0.160 10.0 10 0.050 1.0 
160         
 200 108 0.540 26.0 53 0.265 17.0 54 0.270 17.5 1 0.005 1.0 
300         
 200 175 0.875 36.0 97 0.485 28.5 77 0.385 25.5 1 0.005 1.0 
500         
 70 92 1.314 65.7 21 0.300 21.4 51 0.729 58.6 20 0.286 2.0
Positive Control: Cyclophosphamide 
2.5       
 200 43 0.215 18.0 12 0.060 6.0 31 0.155 14.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 30 0.600 44.0 8 0.160 14.0 22 0.440 34.0 0 0.000 0.0
Trend: 12.468 8.943 11.032  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 12/16/1986    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 6-Methoxy-2-benzothiazolamine 
160         
 200 81 0.405 25.0 27 0.135 10.0 54 0.270 18.5 0 0.000 0.0 
300         
 200 49 0.245 16.5 19 0.095 8.0 30 0.150 12.0 0 0.000 0.0 
500         
 200 65 0.325 28.5 14 0.070 6.5 51 0.255 24.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 36 0.180 17.0 4 0.020 2.0 32 0.160 15.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 20 0.400 28.0 2 0.040 4.0 18 0.360 26.0 0 0.000 0.0
Trend: 6.036 2.333 5.731  
Probability: 0.000 0.010 0.000