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Study Information
Study Attribute Value
CEBS Accession Number: 002-01556-0001-0000-0
Chemical Name: 6-Methylquinoline
CASRN: 91-62-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 741114_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/04/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 412 0.401 8.24 25.5 0.000
Test Chemical 6-Methylquinoline 
 0.2       
 50 998 414 0.415 8.28 25.5 3.506 
 0.5       
 50 992 447 0.451 8.94 25.5 12.432 
16.7       
 50 1010 506 0.501 10.12 31.2 25.004 
50.1       
 0 0 0 0.000 0.00 31.2 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1016 569 0.560 11.38 25.5 39.738
Mitomycin-C 
 0.01      
 5 106 136 1.283 27.20 25.5 220.132
Trend: 3.634        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/25/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 510 216 0.424 8.64 25.8 0.000
Test Chemical 6-Methylquinoline 
16.6       
 25 514 270 0.525 10.80 32.4 24.027 
25.1       
 25 523 297 0.568 11.88 32.4 34.082 
33         
 25 512 312 0.609 12.48 32.4 43.880 
50         
 0 0 0 0.000 0.00 32.4 N/A
Positive Control Mitomycin-C 
 0.001     
 25 523 281 0.537 11.24 25.8 26.859
Mitomycin-C 
 0.01      
 5 104 182 1.750 36.40 25.8 313.194
Trend: 4.183        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/04/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 407 0.396 8.14 25.5 0.000
Test Chemical 6-Methylquinoline 
16.7       
 25 520 503 0.967 20.12 25.5 144.322 
50.1       
 25 509 586 1.151 23.44 25.5 190.789 
166.9       
 10 208 330 1.587 33.00 31.2 300.728 
500.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1025 664 0.648 13.28 25.5 63.622
Cyclophosphamide 
2         
 5 103 170 1.650 34.00 25.5 316.879
Trend: 21.136        
Probability: 0.000