COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01556-0001-0000-0
Chemical Name: 6-Methylquinoline
CASRN: 91-62-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 741114_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Weakly Positive 
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/04/1986    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1028 412 0.401 8.24 25.5 0.000
Test Chemical 6-Methylquinoline
 0.2       
50 998 414 0.415 8.28 25.5 3.506
 0.5       
50 992 447 0.451 8.94 25.5 12.432
16.7       
50 1010 506 0.501 10.12 31.2 25.004
50.1       
0 0 0 0.000 0.00 31.2 N/A
Positive Control Mitomycin-C
 0.001     
50 1016 569 0.560 11.38 25.5 39.738
Mitomycin-C
 0.01      
5 106 136 1.283 27.20 25.5 220.132
Trend: 3.634        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/25/1986    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
25 510 216 0.424 8.64 25.8 0.000
Test Chemical 6-Methylquinoline
16.6       
25 514 270 0.525 10.80 32.4 24.027
25.1       
25 523 297 0.568 11.88 32.4 34.082
33         
25 512 312 0.609 12.48 32.4 43.880
50         
0 0 0 0.000 0.00 32.4 N/A
Positive Control Mitomycin-C
 0.001     
25 523 281 0.537 11.24 25.8 26.859
Mitomycin-C
 0.01      
5 104 182 1.750 36.40 25.8 313.194
Trend: 4.183        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/04/1986    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1028 407 0.396 8.14 25.5 0.000
Test Chemical 6-Methylquinoline
16.7       
25 520 503 0.967 20.12 25.5 144.322
50.1       
25 509 586 1.151 23.44 25.5 190.789
166.9       
10 208 330 1.587 33.00 31.2 300.728
500.7       
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.4       
50 1025 664 0.648 13.28 25.5 63.622
Cyclophosphamide
2         
5 103 170 1.650 34.00 25.5 316.879
Trend: 21.136        
Probability: 0.000