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Study Information
Study Attribute Value
CEBS Accession Number: 002-01556-0002-0000-1
Chemical Name: 6-Methylquinoline
CASRN: 91-62-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 741114_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 04/23/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 6 0.030 2.5 4 0.020 2.0 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 6-Methylquinoline 
52.7       
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
69.9       
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
174.8       
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
349.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 20 0.100 9.0 13 0.065 5.5 7 0.035 3.5 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 14 0.560 40.0 12 0.480 32.0 2 0.080 8.0 0 0.000 0.0
Trend: -1.821 -1.393 -1.282  
Probability: 0.966 0.918 0.900  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/14/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 6-Methylquinoline 
149.3       
 25 72 2.880 48.0 4 0.160 8.0 8 0.320 20.0 60 2.400 24.0 
199.1       
 25 78 3.120 52.0 11 0.440 20.0 7 0.280 20.0 60 2.400 24.0 
248.9       
 10 47 4.700 90.0 12 1.200 60.0 5 0.500 30.0 30 3.000 30.0 
299.9       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 15 0.150 13.0 3 0.030 3.0 12 0.120 10.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 12 0.480 40.0 5 0.200 20.0 7 0.280 24.0 0 0.000 0.0
Trend: 7.896 5.688 4.282  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 04/23/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 7 0.035 3.5 5 0.025 2.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: 6-Methylquinoline 
50.3       
 200 4 0.020 1.0 4 0.020 1.0 0 0.000 0.0 0 0.000 0.0 
125.5       
 50 68 1.360 32.0 19 0.380 14.0 9 0.180 18.0 40 0.800 8.0 
250.9       
 25 53 2.120 56.0 19 0.760 36.0 4 0.160 16.0 30 1.200 12.0 
374.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 18 0.090 8.0 13 0.065 5.5 5 0.025 2.5 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 14 0.560 40.0 5 0.200 20.0 9 0.360 24.0 0 0.000 0.0
Trend: 9.587 6.686 6.136  
Probability: 0.000 0.000 0.000