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Study Information
Study Attribute Value
CEBS Accession Number: 002-01565-0001-0000-0
Chemical Name: 7-Methylquinoline
CASRN: 612-60-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 385846_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/05/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1016 367 0.361 7.34 25.5 0.000
Test Chemical 7-Methylquinoline 
5         
 50 1008 381 0.378 7.62 25.5 4.639 
16.6       
 50 1027 481 0.468 9.62 31.8 29.659 
49.9       
 50 1019 490 0.481 9.80 31.8 33.122 
166.2       
 0 0 0 0.000 0.00 31.8 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1005 515 0.512 10.30 25.5 41.863
Mitomycin-C 
 0.01      
 5 105 174 1.657 34.80 25.5 358.762
Trend: 4.951        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/04/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 519 219 0.422 8.76 25.5 0.000
Test Chemical 7-Methylquinoline 
25.1       
 25 512 270 0.527 10.80 32.0 24.973 
50.2       
 25 516 279 0.541 11.16 32.0 28.138 
74.9       
 25 508 307 0.604 12.28 32.0 43.218 
99.8       
 0 0 0 0.000 0.00 32.0 N/A
Positive Control Mitomycin-C 
 0.001     
 25 506 289 0.571 11.56 25.5 35.354
Mitomycin-C 
 0.01      
 5 104 155 1.490 31.00 25.5 253.201
Trend: 3.830        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/05/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1035 443 0.428 8.86 25.5 0.000
Test Chemical 7-Methylquinoline 
16.6       
 25 515 681 1.322 27.24 31.8 208.942 
49.9       
 25 509 612 1.202 24.48 31.8 180.912 
166.2       
 25 510 665 1.304 26.60 31.8 204.641 
498.6       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1035 754 0.729 15.08 25.5 70.203
Cyclophosphamide 
2         
 5 103 279 2.709 55.80 25.5 532.854
Trend: 18.109        
Probability: 0.000