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Study Information
Study Attribute Value
CEBS Accession Number: 002-01565-0002-0000-1
Chemical Name: 7-Methylquinoline
CASRN: 612-60-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 385846_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 04/15/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 7-Methylquinoline 
225.5       
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
250.3       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
275         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
301.6       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 22 0.220 17.0 5 0.050 5.0 17 0.170 15.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 24 0.960 44.0 7 0.280 20.0 17 0.680 36.0 0 0.000 0.0
Trend: 0.674 0.195 1.394  
Probability: 0.250 0.423 0.082  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/18/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 1.5 2 0.010 1.0 2 0.010 0.5 0 0.000 0.0
Test Chemical: 7-Methylquinoline 
25.1       
 200 25 0.125 6.0 8 0.040 3.0 17 0.085 5.0 0 0.000 0.0 
37.4       
 200 32 0.160 10.5 10 0.050 3.5 22 0.110 8.5 0 0.000 0.0 
49.8       
 200 75 0.375 15.0 23 0.115 8.0 32 0.160 10.0 20 0.100 1.0 
124.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 26 0.130 10.0 6 0.030 3.0 20 0.100 7.5 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 21 0.840 40.0 5 0.200 16.0 16 0.640 32.0 0 0.000 0.0
Trend: 5.125 3.372 4.342  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 03/18/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 7-Methylquinoline 
149.4       
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
226.3       
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
301.7       
 200 23 0.115 2.5 0 0.000 0.0 3 0.015 1.5 20 0.100 1.0 
402.3       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 54 0.270 15.0 26 0.130 10.5 18 0.090 7.0 10 0.050 0.5
Mitomycin-C 
 0.08      
 25 18 0.720 48.0 9 0.360 36.0 9 0.360 20.0 0 0.000 0.0
Trend: 1.388 0.785 0.431  
Probability: 0.083 0.216 0.333  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 04/24/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 7-Methylquinoline 
50         
 100 46 0.460 11.0 11 0.110 5.0 15 0.150 8.0 20 0.200 2.0 
124.5       
 10 42 4.200 70.0 21 2.100 60.0 11 1.100 50.0 10 1.000 10.0 
150         
 10 42 4.200 80.0 24 2.400 70.0 8 0.800 40.0 10 1.000 10.0
Positive Control: Cyclophosphamide 
6.25      
 100 14 0.140 11.0 4 0.040 4.0 10 0.100 8.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 10 0.400 28.0 2 0.080 8.0 8 0.320 24.0 0 0.000 0.0
Trend: 8.273 8.285 6.118  
Probability: 0.000 0.000 0.000