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Study Information
Study Attribute Value
CEBS Accession Number: 002-01567-0001-0000-2
Chemical Name: 8-Hydroxyquinoline
CASRN: 148-24-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 592699_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/04/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 355 0.340 7.10 27.0 0.000
Test Chemical 8-Hydroxyquinoline 
 0.255     
 50 1048 327 0.312 6.54 27.0 -8.151 
 0.85      
 50 1048 330 0.315 6.60 27.0 -7.308 
2.55      
 50 1046 430 0.411 8.60 31.0 21.011 
8.5       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1045 505 0.483 10.10 27.0 42.254
Mitomycin-C 
 0.01      
 10 211 254 1.204 25.40 27.0 254.356
Trend: 2.618        
Probability: 0.004        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/04/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 390 0.374 7.80 26.0 0.000
Test Chemical 8-Hydroxyquinoline 
 0.85      
 50 1036 393 0.379 7.86 26.0 1.547 
2.55      
 50 1038 412 0.397 8.24 26.0 6.252 
8.5       
 50 1045 622 0.595 12.44 26.0 59.335
Positive Control Cyclophosphamide 
 0.4       
 50 1048 536 0.511 10.72 26.0 36.911
Cyclophosphamide 
2.5       
 12 248 317 1.278 26.42 26.0 242.171
Trend: 7.540        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/09/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 413 0.395 8.26 26.0 0.000
Test Chemical 8-Hydroxyquinoline 
7.5       
 50 1039 696 0.670 13.92 26.0 69.658 
10         
 50 1042 708 0.679 14.16 26.0 72.087 
15         
 50 1036 789 0.762 15.78 26.0 92.885 
20         
 50 1045 782 0.748 15.64 26.0 89.527
Positive Control Cyclophosphamide 
 0.4       
 50 1048 583 0.556 11.66 26.0 40.893
Cyclophosphamide 
2.5       
 10 210 253 1.205 25.30 26.0 205.129
Trend: 10.113        
Probability: 0.000