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Study Information
Study Attribute Value
CEBS Accession Number: 002-01567-0002-0000-3
Chemical Name: 8-Hydroxyquinoline
CASRN: 148-24-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 592699_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 06/27/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 8-Hydroxyquinoline 
 0.94      
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
2.83      
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
9.4       
 100 6 0.060 5.0 1 0.010 1.0 5 0.050 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 100 27 0.270 21.0 12 0.120 11.0 14 0.140 13.0 1 0.010 1.0
Mitomycin-C 
5         
 50 31 0.620 40.0 9 0.180 12.0 22 0.440 32.0 0 0.000 0.0
Trend: 1.567 0.014 1.840  
Probability: 0.059 0.495 0.033  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/27/1985    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 8-Hydroxyquinoline 
 0.94      
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
2.83      
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
9.4       
 100 18 0.180 12.0 9 0.090 8.0 9 0.090 7.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 33 0.660 36.0 8 0.160 14.0 15 0.300 26.0 10 0.200 1.0
Trend: 3.467 3.877 2.080  
Probability: 0.000 0.000 0.019  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 07/29/1985    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 6 0.060 2.0 0 0.000 0.0 6 0.060 2.0 0 0.000 0.0
Test Chemical: 8-Hydroxyquinoline 
3         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
5         
 100 20 0.200 7.0 2 0.020 1.0 8 0.080 6.0 10 0.100 1.0 
7.5       
 100 22 0.220 10.0 4 0.040 3.0 7 0.070 6.0 11 0.110 2.0
Positive Control: Cyclophosphamide 
50         
 15 30 2.000 73.0 10 0.667 40.0 20 1.333 73.0 0 0.000 0.0
Trend: 3.087 2.220 2.036  
Probability: 0.001 0.013 0.021