COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01567-0002-0000-3
Chemical Name: 8-Hydroxyquinoline
CASRN: 148-24-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 592699_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 06/27/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 8-Hydroxyquinoline
 0.94      
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
2.83      
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
9.4       
100 6 0.060 5.0 1 0.010 1.0 5 0.050 4.0 0 0.000 0.0
Positive Control: Mitomycin-C
1         
100 27 0.270 21.0 12 0.120 11.0 14 0.140 13.0 1 0.010 1.0
Mitomycin-C
5         
50 31 0.620 40.0 9 0.180 12.0 22 0.440 32.0 0 0.000 0.0
Trend: 1.567 0.014 1.840  
Probability: 0.059 0.495 0.033  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/27/1985    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 8-Hydroxyquinoline
 0.94      
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
2.83      
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
9.4       
100 18 0.180 12.0 9 0.090 8.0 9 0.090 7.0 0 0.000 0.0
Positive Control: Cyclophosphamide
50         
50 33 0.660 36.0 8 0.160 14.0 15 0.300 26.0 10 0.200 1.0
Trend: 3.467 3.877 2.080  
Probability: 0.000 0.000 0.019  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 07/29/1985    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 6 0.060 2.0 0 0.000 0.0 6 0.060 2.0 0 0.000 0.0
Test Chemical: 8-Hydroxyquinoline
3         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
5         
100 20 0.200 7.0 2 0.020 1.0 8 0.080 6.0 10 0.100 1.0
7.5       
100 22 0.220 10.0 4 0.040 3.0 7 0.070 6.0 11 0.110 2.0
Positive Control: Cyclophosphamide
50         
15 30 2.000 73.0 10 0.667 40.0 20 1.333 73.0 0 0.000 0.0
Trend: 3.087 2.220 2.036  
Probability: 0.001 0.013 0.021