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Study Information
Study Attribute Value
CEBS Accession Number: 002-01567-0003-0000-4
Chemical Name: 8-Hydroxyquinoline
CASRN: 148-24-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 616445_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/24/1987    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1037 432 0.417 8.64 26.0 0.000
Test Chemical 8-Hydroxyquinoline 
 0.16      
 50 1045 385 0.368 7.70 26.0 -11.562 
1.6       
 0 0 0 0.000 0.00 26.0 N/A 
5         
 0 0 0 0.000 0.00 26.0 N/A 
16         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 553 0.527 11.06 26.0 26.424
Mitomycin-C 
 0.005     
 10 210 306 1.457 30.60 26.0 249.782
Trend: -1.754        
Probability: 0.960        

Trial #: 2    Activation: No Activation    Date: 09/24/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 430 0.410 8.60 26.0 0.000
Test Chemical 8-Hydroxyquinoline 
 0.16      
 50 1049 420 0.400 8.40 26.0 -2.419 
 0.5       
 50 1048 401 0.383 8.02 26.0 -6.744 
1.6       
 50 1043 403 0.386 8.06 26.0 -5.830
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 568 0.541 11.36 26.0 31.841
Mitomycin-C 
 0.005     
 10 209 213 1.019 21.30 26.0 148.385
Trend: -1.029        
Probability: 0.848        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/24/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 431 0.410 8.62 26.0 0.000
Test Chemical 8-Hydroxyquinoline 
 0.16      
 50 1048 544 0.519 10.88 26.0 26.459 
5         
 50 1049 573 0.546 11.46 26.0 33.073
Positive Control Cyclophosphamide 
 0.1       
 50 1049 520 0.496 10.40 26.0 20.765
Cyclophosphamide 
 0.6       
 10 210 232 1.105 23.20 26.0 169.142
Trend: 4.435        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/11/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 362 0.346 7.24 26.0 0.000
Test Chemical 8-Hydroxyquinoline 
 0.5       
 50 1050 453 0.431 9.06 26.0 24.781 
1         
 22 454 202 0.445 9.18 26.0 28.687 
1.6       
 50 1047 568 0.543 11.36 26.0 56.906 
5         
 50 1051 547 0.520 10.94 26.0 50.530 
10         
 7 146 103 0.705 14.71 26.0 104.043
Positive Control Cyclophosphamide 
 0.1       
 50 1045 474 0.454 9.48 26.0 31.190
Cyclophosphamide 
 0.6       
 10 210 232 1.105 23.20 26.0 219.526
Trend: 7.638        
Probability: 0.000