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Study Information
Study Attribute Value
CEBS Accession Number: 002-01567-0004-0000-5
Chemical Name: 8-Hydroxyquinoline
CASRN: 148-24-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 616445_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Questionable 

Trial #:1   Activation: No Activation    Date: 10/21/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 8-Hydroxyquinoline
 0.5       
200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0
1.6       
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
5         
200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.0625    
200 23 0.115 11.5 6 0.030 3.0 17 0.085 8.5 0 0.000 0.0
Mitomycin-C
 0.25      
50 18 0.360 32.0 3 0.060 6.0 15 0.300 26.0 0 0.000 0.0
Trend: 0.221 0.629 -0.004  
Probability: 0.413 0.265 0.501  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/16/1987    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: 8-Hydroxyquinoline
3         
200 7 0.035 3.5 3 0.015 1.5 4 0.020 2.0 0 0.000 0.0
5         
200 6 0.030 2.5 1 0.005 0.5 5 0.025 2.0 0 0.000 0.0
10         
50 75 1.500 48.0 39 0.780 32.0 26 0.520 28.0 10 0.200 1.0
Positive Control: Cyclophosphamide
5         
200 48 0.240 19.5 9 0.045 4.5 39 0.195 16.0 0 0.000 0.0
Cyclophosphamide
7.5       
50 20 0.400 34.0 6 0.120 12.0 14 0.280 24.0 0 0.000 0.0
Trend: 8.495 7.226 6.526  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/21/1987    Harvest Time: 13 hour(s)   Trial Call: Questionable   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: 8-Hydroxyquinoline
 0.5       
200 7 0.035 3.5 0 0.000 0.0 7 0.035 3.5 0 0.000 0.0
1.6       
200 8 0.040 4.0 0 0.000 0.0 8 0.040 4.0 0 0.000 0.0
5         
200 9 0.045 4.5 0 0.000 0.0 9 0.045 4.5 0 0.000 0.0
16         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
2.5       
200 23 0.115 11.5 2 0.010 1.0 21 0.105 10.5 0 0.000 0.0
Cyclophosphamide
7.5       
50 22 0.440 42.0 6 0.120 10.0 16 0.320 32.0 0 0.000 0.0
Trend: 1.963 -1.344 2.274  
Probability: 0.025 0.911 0.011