Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01567-0004-0000-5 |
Chemical Name: | 8-Hydroxyquinoline |
CASRN: | 148-24-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 616445_CA |
Study Result: | Weakly Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Weakly Positive* |
Induced Rat Liver S9 | 2_S9 | Questionable |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Test Chemical: | 8-Hydroxyquinoline | 0.5 | 200 | 6 | 0.030 | 3.0 | 1 | 0.005 | 0.5 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 |
1.6 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
5 | 200 | 5 | 0.025 | 2.5 | 1 | 0.005 | 0.5 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 23 | 0.115 | 11.5 | 6 | 0.030 | 3.0 | 17 | 0.085 | 8.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 18 | 0.360 | 32.0 | 3 | 0.060 | 6.0 | 15 | 0.300 | 26.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.221 | 0.629 | -0.004 | ||||||||||||
Probability: | 0.413 | 0.265 | 0.501 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | 8-Hydroxyquinoline | 3 | 200 | 7 | 0.035 | 3.5 | 3 | 0.015 | 1.5 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
5 | 200 | 6 | 0.030 | 2.5 | 1 | 0.005 | 0.5 | 5 | 0.025 | 2.0 | 0 | 0.000 | 0.0 | ||
10 | 50 | 75 | 1.500 | 48.0 | 39 | 0.780 | 32.0 | 26 | 0.520 | 28.0 | 10 | 0.200 | 1.0 | ||
Positive Control: | Cyclophosphamide | 5 | 200 | 48 | 0.240 | 19.5 | 9 | 0.045 | 4.5 | 39 | 0.195 | 16.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 20 | 0.400 | 34.0 | 6 | 0.120 | 12.0 | 14 | 0.280 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 8.495 | 7.226 | 6.526 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | 8-Hydroxyquinoline | 0.5 | 200 | 7 | 0.035 | 3.5 | 0 | 0.000 | 0.0 | 7 | 0.035 | 3.5 | 0 | 0.000 | 0.0 |
1.6 | 200 | 8 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 8 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
5 | 200 | 9 | 0.045 | 4.5 | 0 | 0.000 | 0.0 | 9 | 0.045 | 4.5 | 0 | 0.000 | 0.0 | ||
16 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 23 | 0.115 | 11.5 | 2 | 0.010 | 1.0 | 21 | 0.105 | 10.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 22 | 0.440 | 42.0 | 6 | 0.120 | 10.0 | 16 | 0.320 | 32.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.963 | -1.344 | 2.274 | ||||||||||||
Probability: | 0.025 | 0.911 | 0.011 |