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Study Information
Study Attribute Value
CEBS Accession Number: 002-01567-0018-0000-0
Chemical Name: 8-Hydroxyquinoline
CASRN: 148-24-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 980523
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 78 100 128 55 51
    76 87 96 42
    96 97 162 57
    101 116 154 51
Test Chemical 8-Hydroxyquinoline 
 0.2       
 72 80 107 50 52
    73 80 119 55
  
 0.4       
 64 93 78 41 50
    68 88 120 59
  
 0.8       
 98 78 197 67 68
    69 71 140 68
  
1.6       
 81 31 283 116 113*
    93 30 305 110
  
3.2       
 58 10 292 166 158*
    77 12 342 149
Positive Control Methyl Methane Sulfonate 
15         
 26 15 488 626 591*
    22 14 370 556

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 72 91 155 72 63
    64 103 120 63
    90 106 145 54
    46r 62 135 98
Test Chemical 8-Hydroxyquinoline 
 0.1       
 73 90 160 73 84
    73 83 205 94
  
 0.2       
 103# 119 165 54 55
    87 105 145 56
  
 0.4       
 68# 94 206 102 104*
    86 83 273 106
  
 0.8       
 82 65 251 102 115*
    70 63 268 128
  
1.5       
 68 4 460 227 224*
    63 4 419 222
  
2.2       
   
Positive Control Methyl Methane Sulfonate 
15         
 31 20 382 417 354*
    32 23 274 290

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination