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Study Information
Study Attribute Value
CEBS Accession Number: 002-01567-0019-0000-1
Chemical Name: 8-Hydroxyquinoline
CASRN: 148-24-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 470651_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 09/30/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.51 ± 0.401
Test Chemical 8-Hydroxyquinoline 
25         
 4 3.92 ± 0.531
  
50         
 4 4.55 ± 0.679
  
100         
 4 4.59 ± 0.449
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.34 ± 0.542


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/20/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.56 ± 0.405
Test Chemical 8-Hydroxyquinoline 
25         
 4 3.89 ± 0.430
  
50         
 4 4.90 ± 0.458
  
100         
 4 4.99 ± 1.064
Positive Control Dimethylbenzanthracene 
2.5       
 4 10.59 ± 0.688


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/12/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.70 ± 0.977
Test Chemical 8-Hydroxyquinoline 
17.5       
 4 4.63 ± 0.259
  
35         
 4 3.61 ± 0.696
  
70         
 4 4.00 ± 0.234
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.27 ± 0.964


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed