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Study Information
Study Attribute Value
CEBS Accession Number: 002-01567-0020-0000-3
Chemical Name: 8-Hydroxyquinoline
CASRN: 148-24-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 470651_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/25/85 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2234
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 12.00 ± 1.31 0.0000
Test Chemical 8-Hydroxyquinoline 
25         
 8 1.50 ± 0.63 0.0776
  
50         
 8 1.75 ± 0.59 0.0469
  
100         
 8 1.25 ± 0.75 0.1274
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/20/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.1633
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 39.25 ± 5.50 0.0000
Test Chemical 8-Hydroxyquinoline 
17.5       
 8 4.25 ± 0.80 0.6335
  
35         
 8 4.50 ± 1.76 0.5668
  
70         
 8 6.00 ± 2.04 0.2166
Vehicle Control No Stressor 
 0         
 8 4.75 ± 1.31 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed