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Study Information
Study Attribute Value
CEBS Accession Number: 002-01568-0009-0000-1
Chemical Name: 8-Methoxypsoralen
CASRN: 298-81-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 501444_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/29/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 5.75 ± 2.25 0.0000
Test Chemical 8-Methoxypsoralen 
50         
 8 1.00 ± 0.76 0.0892
  
100         
 8 0.50 ± 0.33 0.2815
  
200         
 8 8.00 ± 0.00 0.0000
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/30/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 2.25 ± 1.22 0.0055
Test Chemical 8-Methoxypsoralen 
50         
 8 0.89 ± 0.38 0.0892
  
100         
 8 2.75 ± 0.00 0.0018
  
200         
 4 9.09 ± 0.00 0.0000
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed