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Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01568-0009-0000-1 |
Chemical Name: | 8-Methoxypsoralen |
CASRN: | 298-81-7 |
NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
NTP Study ID: | 501444_CA |
Study Result: | Positive |
Test Type | Start Date | Sample Time (h) | Species | Sex | Tissue | Protocol | Trend Test P |
---|---|---|---|---|---|---|---|
CA | 05/29/91 | 17 | Mouse | Male | Bone Marrow | Intraperitoneal Injection x 1/study, 17 hour | 0.0000 |
Test Group | Dose (mg/kg) |
n | Percent Cells w/ Aberrations (Mean ± SEM) |
Pairwise P | |
---|---|---|---|---|---|
Positive Control | Dimethylbenzanthracene | 100 |
8 | 5.75 ± 2.25 | 0.0000 |
Test Chemical | 8-Methoxypsoralen | 50 |
8 | 1.00 ± 0.76 | 0.0892 |
100 |
8 | 0.50 ± 0.33 | 0.2815 | ||
200 |
8 | 8.00 ± 0.00 | 0.0000 | ||
Vehicle Control | No Stressor | 0 |
8 | 0.25 ± 0.25 | 0.0000 |
Test Type | Start Date | Sample Time (h) | Species | Sex | Tissue | Protocol | Trend Test P |
---|---|---|---|---|---|---|---|
CA | 07/30/91 | 17 | Mouse | Male | Bone Marrow | Intraperitoneal Injection x 1/study, 17 hour | 0.0000 |
Test Group | Dose (mg/kg) |
n | Percent Cells w/ Aberrations (Mean ± SEM) |
Pairwise P | |
---|---|---|---|---|---|
Positive Control | Dimethylbenzanthracene | 100 |
8 | 2.25 ± 1.22 | 0.0055 |
Test Chemical | 8-Methoxypsoralen | 50 |
8 | 0.89 ± 0.38 | 0.0892 |
100 |
8 | 2.75 ± 0.00 | 0.0018 | ||
200 |
4 | 9.09 ± 0.00 | 0.0000 | ||
Vehicle Control | No Stressor | 0 |
8 | 0.25 ± 0.25 | 0.0000 |