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Study Information
Study Attribute Value
CEBS Accession Number: 002-01569-0001-0000-4
Chemical Name: 8-Methylquinoline
CASRN: 611-32-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 233055_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/04/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 450 0.437 9.00 25.5 0.000
Test Chemical 8-Methylquinoline 
5         
 50 1029 445 0.432 8.90 25.5 -1.111 
16.8       
 50 1020 527 0.517 10.54 31.2 18.144 
50.4       
 50 1029 495 0.481 9.90 31.2 10.000 
167.9       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1028 554 0.539 11.08 25.5 23.231
Mitomycin-C 
 0.01      
 5 104 201 1.933 40.20 25.5 341.942
Trend: 2.296        
Probability: 0.011        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/04/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1034 445 0.430 8.90 25.5 0.000
Test Chemical 8-Methylquinoline 
16.8       
 50 1013 606 0.598 12.12 25.5 39.003 
50.4       
 50 1015 600 0.591 12.00 25.5 37.355 
167.9       
 50 1029 727 0.707 14.54 25.5 64.165 
503.8       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1026 704 0.686 14.08 25.5 59.436
Cyclophosphamide 
2         
 5 102 156 1.529 31.20 25.5 255.373
Trend: 7.764        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/26/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 515 222 0.431 8.88 25.5 0.000
Test Chemical 8-Methylquinoline 
100.6       
 25 513 396 0.772 15.84 25.5 79.074 
167.6       
 25 512 469 0.916 18.76 25.5 112.499 
250.1       
 25 503 458 0.911 18.32 25.5 111.228 
373.3       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 25 519 410 0.790 16.40 25.5 83.261
Cyclophosphamide 
2         
 5 101 213 2.109 42.60 25.5 389.229
Trend: 9.278        
Probability: 0.000