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Study Information
Study Attribute Value
CEBS Accession Number: 002-01569-0002-0000-5
Chemical Name: 8-Methylquinoline
CASRN: 611-32-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 233055_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 03/19/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 5 0.025 1.5 1 0.005 0.5 4 0.020 1.5 0 0.000 0.0
Test Chemical: 8-Methylquinoline 
19.9       
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0 
49.8       
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
99.5       
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
150.7       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 50 0.250 18.5 26 0.130 11.5 24 0.120 11.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 26 1.040 56.0 10 0.400 24.0 16 0.640 48.0 0 0.000 0.0
Trend: 0.463 0.007 0.083  
Probability: 0.322 0.497 0.467  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/15/1986    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 8-Methylquinoline 
199.3       
 100 36 0.360 28.0 9 0.090 8.0 27 0.270 23.0 0 0.000 0.0 
249.1       
 25 28 1.120 76.0 9 0.360 24.0 19 0.760 68.0 0 0.000 0.0 
300.1       
 25 26 1.040 80.0 6 0.240 16.0 20 0.800 76.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 9 0.090 9.0 4 0.040 4.0 5 0.050 5.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 17 0.680 48.0 8 0.320 28.0 9 0.360 32.0 0 0.000 0.0
Trend: 9.815 4.148 9.465  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 03/19/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: 8-Methylquinoline 
39.8       
 200 25 0.125 10.0 7 0.035 3.5 18 0.090 6.5 0 0.000 0.0 
99.5       
 200 27 0.135 12.0 12 0.060 6.0 15 0.075 6.0 0 0.000 0.0 
198.9       
 50 25 0.500 42.0 4 0.080 8.0 21 0.420 38.0 0 0.000 0.0 
301.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 57 0.285 18.5 22 0.110 10.0 35 0.175 12.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 21 0.840 44.0 5 0.200 20.0 16 0.640 36.0 0 0.000 0.0
Trend: 6.716 3.341 6.127  
Probability: 0.000 0.000 0.000