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Study Information
Study Attribute Value
CEBS Accession Number: 002-01571-0002-0000-8
Chemical Name: 9-Aminoacridine, monohydrochloride, monohydrate
CASRN: 52417-22-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 686905_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 04/03/1984    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 9-Aminoacridine, monohydrochloride, monohydrate 
1.25      
 50 32 0.640 32.0 8 0.160 16.0 22 0.440 18.0 2 0.040 4.0 
1.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
2         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
2.5       
 50 12 0.240 20.0 8 0.160 12.0 4 0.080 8.0 0 0.000 0.0 
3         
 50 42 0.840 50.0 21 0.420 36.0 21 0.420 30.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.035     
 100 15 0.150 13.0 8 0.080 8.0 6 0.060 5.0 1 0.010 1.0
Mitomycin-C 
 0.0625    
 50 21 0.420 24.0 10 0.200 16.0 11 0.220 16.0 0 0.000 0.0
Trend: 5.818 5.148 4.117  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/03/1984    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 9-Aminoacridine, monohydrochloride, monohydrate 
12.5       
 100 20 0.200 16.0 12 0.120 9.0 3 0.030 3.0 5 0.050 5.0 
15         
 50 35 0.700 42.0 18 0.360 22.0 13 0.260 18.0 4 0.080 8.0 
17.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
20         
 50 51 1.020 50.0 18 0.360 24.0 22 0.440 36.0 11 0.220 4.0 
22.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 100 6 0.060 6.0 4 0.040 4.0 2 0.020 2.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 18 0.720 44.0 11 0.440 32.0 7 0.280 24.0 0 0.000 0.0
Trend: 7.533 4.756 7.166  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 04/19/1984    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 50 1 0.020 2.0 0 0.000 0.0 1 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 50 1 0.020 2.0 1 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 9-Aminoacridine, monohydrochloride, monohydrate 
2         
 50 6 0.120 12.0 4 0.080 8.0 2 0.040 4.0 0 0.000 0.0 
2.5       
 50 16 0.320 22.0 10 0.200 18.0 6 0.120 8.0 0 0.000 0.0 
3         
 25 14 0.560 48.0 13 0.520 44.0 1 0.040 4.0 0 0.000 0.0 
4         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.035     
 50 12 0.240 14.0 5 0.100 8.0 6 0.120 10.0 1 0.020 2.0
Mitomycin-C 
 0.0625    
 25 12 0.480 32.0 5 0.200 16.0 7 0.280 16.0 0 0.000 0.0
Trend: 4.867 4.688 1.569  
Probability: 0.000 0.000 0.058