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Study Information
Study Attribute Value
CEBS Accession Number: 002-01572-0001-0000-8
Chemical Name: 9-Nitroanthracene
CASRN: 602-60-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 823748_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/18/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 467 0.450 9.34 25.6 0.000
Test Chemical 9-Nitroanthracene 
5         
 50 1034 782 0.756 15.64 25.6 68.100 
16.7       
 50 1034 806 0.779 16.12 32.8 73.259 
50         
 50 1031 895 0.868 17.90 32.8 92.950 
166.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1033 652 0.631 13.04 25.6 40.290
Mitomycin-C 
 0.01      
 5 104 169 1.625 33.80 25.6 261.188
Trend: 10.911        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/18/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1034 475 0.459 9.50 25.6 0.000
Test Chemical 9-Nitroanthracene 
50         
 50 1040 750 0.721 15.00 32.8 56.984 
166.7       
 50 1030 776 0.753 15.52 32.8 64.003 
500         
 50 1039 753 0.725 15.06 32.8 57.763
Positive Control Cyclophosphamide 
 0.3       
 50 1045 590 0.565 11.80 25.6 22.903
Cyclophosphamide 
2         
 5 105 132 1.257 26.40 25.6 173.660
Trend: 7.335        
Probability: 0.000