U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01590-0001-0000-8
Chemical Name: Acetin
CASRN: 26446-35-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 041652_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/23/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1040 383 0.368 7.66 26.5 0.000
Test Chemical Acetin 
501         
 50 1046 438 0.419 8.76 26.5 13.704 
1500         
 50 1044 514 0.492 10.28 26.5 33.689 
5010         
 50 1045 811 0.776 16.22 30.5 110.736
Positive Control Mitomycin-C 
 0.002     
 50 1049 790 0.753 15.80 26.5 104.497
Mitomycin-C 
 0.01      
 10 208 351 1.688 35.10 26.5 358.225
Trend: 13.152        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/06/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1046 428 0.409 8.56 26.5 0.000
Test Chemical Acetin 
2000         
 50 1041 584 0.561 11.68 26.5 37.104 
3990         
 50 1045 716 0.685 14.32 26.5 67.450 
4990         
 30 628 497 0.791 16.57 26.5 93.413
Positive Control Mitomycin-C 
 0.0015    
 50 1044 730 0.699 14.60 26.5 70.887
Mitomycin-C 
 0.01      
 10 208 348 1.673 34.80 26.5 308.887
Trend: 10.734        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/23/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 456 0.435 9.12 25.5 0.000
Test Chemical Acetin 
501         
 50 1032 460 0.446 9.20 25.5 2.539 
1500         
 50 1034 485 0.469 9.70 25.5 7.903 
5010         
 50 1038 514 0.495 10.28 25.5 13.914
Positive Control Cyclophosphamide 
 0.5       
 50 1047 673 0.643 13.46 25.5 47.870
Cyclophosphamide 
2.5       
 10 208 299 1.438 29.90 25.5 230.688
Trend: 2.177        
Probability: 0.015