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Study Information
Study Attribute Value
CEBS Accession Number: 002-01592-0001-0000-0
Chemical Name: Acetohexamide
CASRN: 968-81-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 722971_SCE
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  1  Test Failure 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/17/1985    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 513 0.490 10.26 26.0 0.000
Test Chemical Acetohexamide 
16         
 50 1049 469 0.447 9.38 26.0 -8.664 
50         
 50 1047 535 0.511 10.70 26.0 4.388 
160         
 50 1051 456 0.434 9.12 26.0 -11.365 
500         
 50 1050 519 0.494 10.38 26.0 0.977 
1600         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 603 0.574 12.06 26.0 17.320
Mitomycin-C 
 0.005     
 10 210 243 1.157 24.30 26.0 136.391
Trend: -0.063        
Probability: 0.525        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/17/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 475 0.454 9.50 26.0 0.000
Test Chemical Acetohexamide 
160         
 50 1048 461 0.440 9.22 26.0 -3.040 
500         
 50 1048 480 0.458 9.60 26.0 0.956 
1600         
 50 1052 480 0.456 9.60 26.0 0.572 
5000         
 50 1047 457 0.436 9.14 26.0 -3.789
Positive Control Cyclophosphamide 
 0.15      
 50 1049 745 0.710 14.90 26.0 56.543
Cyclophosphamide 
 0.6       
 10 209 337 1.612 33.70 26.0 255.416
Trend: -0.274        
Probability: 0.608