COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01594-0001-0000-2
Chemical Name: Acetone
CASRN: 67-64-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 197425_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/26/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1035 429 0.414 8.58 26.5 0.000
Test Chemical Acetone 
50.2       
 50 1041 444 0.427 8.88 26.5 2.900 
502         
 50 1045 436 0.417 8.72 26.5 0.659 
5020         
 50 1037 425 0.410 8.50 26.5 -1.123
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 579 0.552 11.58 26.5 33.164
Mitomycin-C 
 0.01      
 10 210 776 3.695 77.60 26.5 791.508
Trend: -0.260        
Probability: 0.603        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/26/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1046 397 0.380 7.94 26.0 0.000
Test Chemical Acetone 
502         
 50 1048 318 0.303 6.36 26.0 -20.052 
1510         
 50 1047 349 0.333 6.98 26.0 -12.175 
5020         
 50 1048 374 0.357 7.48 26.0 -5.973
Positive Control Cyclophosphamide 
 0.5       
 50 1043 628 0.602 12.56 26.0 58.641
Cyclophosphamide 
2.5       
 10 210 273 1.300 27.30 26.0 242.519
Trend: -0.460        
Probability: 0.677