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Study Information
Study Attribute Value
CEBS Accession Number: 002-01594-0002-0000-3
Chemical Name: Acetone
CASRN: 67-64-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 197425_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/11/1986    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 10 0.050 5.0 3 0.015 1.5 6 0.030 3.0 1 0.005 1.0
Test Chemical: Acetone 
501         
 200 8 0.040 4.0 3 0.015 1.5 4 0.020 2.0 1 0.005 1.0 
1500         
 200 7 0.035 3.5 0 0.000 0.0 7 0.035 3.5 0 0.000 0.0 
5010         
 200 8 0.040 4.0 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.3       
 200 45 0.225 20.5 17 0.085 8.5 28 0.140 13.0 0 0.000 0.0
Mitomycin-C 
5         
 25 52 2.080 84.0 18 0.720 56.0 24 0.960 56.0 10 0.400 1.0
Trend: -0.550 -0.928 0.274  
Probability: 0.709 0.823 0.392  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/11/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 13 0.065 5.0 2 0.010 1.0 10 0.050 3.5 1 0.005 1.0
Test Chemical: Acetone 
501         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
1500         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
5010         
 200 9 0.045 4.5 4 0.020 2.0 3 0.015 1.5 2 0.010 2.0
Positive Control: Cyclophosphamide 
50         
 50 19 0.380 28.0 15 0.300 24.0 4 0.080 8.0 0 0.000 0.0
Trend: -0.337 0.865 -1.738  
Probability: 0.632 0.194 0.959