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Study Information
Study Attribute Value
CEBS Accession Number: 002-01595-0001-0000-3
Chemical Name: Acetonitrile
CASRN: 75-05-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 119279_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/18/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1042 383 0.368 7.66 26.0 0.000
Test Chemical Acetonitrile 
160         
 50 1049 440 0.419 8.80 26.0 14.116 
500         
 50 1043 428 0.410 8.56 26.0 11.642 
1600         
 50 1050 459 0.437 9.18 26.0 18.930 
5000         
 50 1049 469 0.447 9.38 26.0 21.637
Positive Control Triethylenemelamine 
 0.015     
 50 1050 1442 1.373 28.84 26.0 273.633
Trend: 2.800        
Probability: 0.003        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/18/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1042 408 0.392 8.16 26.0 0.000
Test Chemical Acetonitrile 
500         
 50 1039 431 0.415 8.62 26.0 5.942 
1600         
 50 1039 392 0.377 7.84 26.0 -3.644 
5000         
 50 1037 414 0.399 8.28 26.0 1.960
Positive Control Cyclophosphamide 
1         
 50 1046 910 0.870 18.20 26.0 122.186
Trend: -0.170        
Probability: 0.568