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Study Information
Study Attribute Value
CEBS Accession Number: 002-01595-0002-0000-4
Chemical Name: Acetonitrile
CASRN: 75-05-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 119279_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 

Trial #:1   Activation: No Activation    Date: 11/18/1981    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Acetonitrile 
500         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
1600         
 100 9 0.090 7.0 0 0.000 0.0 9 0.090 7.0 0 0.000 0.0 
5000         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.15      
 50 14 0.280 20.0 2 0.040 4.0 12 0.240 18.0 0 0.000 0.0
Trend: 1.603 -0.003 1.710  
Probability: 0.054 0.501 0.044  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/18/1981    Harvest Time: 14 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Acetonitrile 
500         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
1600         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
5000         
 100 8 0.080 7.0 3 0.030 3.0 5 0.050 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 27 0.540 44.0 2 0.040 4.0 25 0.500 40.0 0 0.000 0.0
Trend: 2.138 2.245 1.050  
Probability: 0.016 0.012 0.147