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Study Information
Study Attribute Value
CEBS Accession Number: 002-01602-0001-0000-2
Chemical Name: Acrolein
CASRN: 107-02-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 134448_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/16/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1048 404 0.385 8.08 26.0 0.000
Test Chemical Acrolein 
 0.1       
 50 1048 464 0.443 9.28 26.0 14.851 
 0.3       
 50 1045 482 0.461 9.64 26.0 19.649 
1         
 50 1047 519 0.496 10.38 26.0 28.588
Positive Control Triethylenemelamine 
 0.015     
 50 1048 1494 1.426 29.88 26.0 269.802
Trend: 3.784        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/16/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1042 430 0.413 8.60 26.0 0.000
Test Chemical Acrolein 
 0.1       
 50 1050 511 0.487 10.22 26.0 17.932 
 0.3       
 50 1045 458 0.438 9.16 26.0 6.206 
1         
 50 1028 476 0.463 9.52 26.0 12.205
Positive Control Cyclophosphamide 
1         
 50 1039 1125 1.083 22.50 26.0 162.383
Trend: 1.116        
Probability: 0.132