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Study Information
Study Attribute Value
CEBS Accession Number: 002-01602-0002-0000-3
Chemical Name: Acrolein
CASRN: 107-02-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 134448_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 04/16/1981    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Acrolein 
 0.1       
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
 0.3       
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
1         
 100 5 0.050 5.0 5 0.050 5.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.15      
 100 32 0.320 27.0 21 0.210 21.0 11 0.110 9.0 0 0.000 0.0
Trend: 1.733 2.965 -0.903  
Probability: 0.042 0.002 0.817  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/16/1981    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Acrolein 
 0.1       
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
 0.3       
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0 
1         
 100 5 0.050 3.0 1 0.010 1.0 4 0.040 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 47 0.470 33.0 29 0.290 23.0 18 0.180 15.0 0 0.000 0.0
Trend: 1.538 0.651 1.839  
Probability: 0.062 0.257 0.033