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Study Information
Study Attribute Value
CEBS Accession Number: 002-01604-0002-0000-5
Chemical Name: Acrylamide
CASRN: 79-06-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 279150_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 05/07/1986    Harvest Time: 12 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Acrylamide 
300         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
500         
 200 19 0.095 9.0 1 0.005 0.5 18 0.090 8.5 0 0.000 0.0 
1000         
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 38 0.190 15.5 15 0.075 6.5 23 0.115 10.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 17 0.340 34.0 2 0.040 4.0 15 0.300 30.0 0 0.000 0.0
Trend: 2.379 -0.049 2.476  
Probability: 0.009 0.519 0.007  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/07/1986    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: Acrylamide 
500         
 200 9 0.045 4.5 2 0.010 1.0 7 0.035 3.5 0 0.000 0.0 
1000         
 200 10 0.050 5.0 1 0.005 0.5 9 0.045 4.5 0 0.000 0.0 
1600         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
3000         
 190 237 1.247 56.3 92 0.484 33.7 125 0.658 43.7 20 0.105 2.0
Positive Control: Cyclophosphamide 
2.5       
 200 20 0.100 10.0 4 0.020 2.0 16 0.080 8.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 19 0.380 34.0 7 0.140 12.0 12 0.240 24.0 0 0.000 0.0
Trend: 13.378 11.389 11.357  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 06/10/1986    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Acrylamide 
1600         
 200 7 0.035 3.5 2 0.010 1.0 5 0.025 2.5 0 0.000 0.0 
2000         
 200 35 0.175 12.5 19 0.095 8.5 16 0.080 7.0 0 0.000 0.0 
2500         
 200 165 0.825 46.5 72 0.360 28.5 93 0.465 31.5 0 0.000 0.0 
3000         
 200 62 0.310 19.0 18 0.090 6.5 44 0.220 16.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 27 0.135 12.0 7 0.035 3.5 20 0.100 9.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 37 0.740 30.0 3 0.060 4.0 14 0.280 26.0 20 0.400 2.0
Trend: 9.823 6.666 8.548  
Probability: 0.000 0.000 0.000