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Study Information
Study Attribute Value
CEBS Accession Number: 002-01604-0028-0000-3
Chemical Name: Acrylamide
CASRN: 79-06-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 549305_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 11/14/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 3.93 ± 0.168
Test Chemical Acrylamide 
40         
 4 8.04 ± 0.691
  
80         
 4 8.75 ± 0.419
  
160         
 4 13.91 ± 0.570
Positive Control Mitomycin-C 
 0.5       
 4 9.40 ± 0.748


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 08/18/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 3 5.17 ± 0.932
Test Chemical Acrylamide 
40         
 4 6.18 ± 0.834
  
80         
 4 6.94 ± 0.095
  
160         
 3 9.42 ± 0.295
Positive Control Mitomycin-C 
 0.5       
 4 4.00 ± 0.145


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed