| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01604-0028-0000-3 |
| Chemical Name: | Acrylamide |
| CASRN: | 79-06-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 549305_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 11/14/85 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Phosphate Buffered Saline | 0 | 4 | 3.93 ± 0.168 | |
| Test Chemical | Acrylamide | 40 | 4 | 8.04 ± 0.691 | |
80 | 4 | 8.75 ± 0.419 | |||
160 | 4 | 13.91 ± 0.570 | |||
| Positive Control | Mitomycin-C | 0.5 | 4 | 9.40 ± 0.748 | |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 08/18/87 | 42 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 42 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Phosphate Buffered Saline | 0 | 3 | 5.17 ± 0.932 | |
| Test Chemical | Acrylamide | 40 | 4 | 6.18 ± 0.834 | |
80 | 4 | 6.94 ± 0.095 | |||
160 | 3 | 9.42 ± 0.295 | |||
| Positive Control | Mitomycin-C | 0.5 | 4 | 4.00 ± 0.145 | |
Footnotes: IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed