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Study Information
Study Attribute Value
CEBS Accession Number: 002-01606-0001-0000-6
Chemical Name: Acrylonitrile
CASRN: 107-13-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 269328_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/08/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 417 0.398 8.34 26.0 0.000
Negative (Not Specified) 
0         
 50 1043 385 0.369 7.70 26.0 -7.143
Test Chemical Acrylonitrile 
 0.16      
 50 1039 397 0.382 7.94 26.0 -3.880 
 0.5       
 50 1036 409 0.395 8.18 26.0 -0.688 
1.6       
 50 1046 418 0.400 8.36 26.0 0.527 
5         
 50 1052 450 0.428 9.00 26.0 7.606 
16         
 50 1045 504 0.482 10.08 26.0 21.326 
50         
 0 0 0 0.000 0.00 0.0 N/A 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1047 2332 2.227 46.64 26.0 460.301
Trend: 3.396        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/18/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 410 0.396 8.20 26.0 0.000
Negative (Not Specified) 
0         
 50 1043 371 0.356 7.42 26.0 -10.119
Test Chemical Acrylonitrile 
10         
 50 1046 535 0.511 10.70 28.0 29.240 
20         
 50 1044 614 0.588 12.28 28.0 48.609 
20         
 50 1049 686 0.654 13.72 38.0 65.244 
30         
 0 0 0 0.000 0.00 28.0 N/A 
30         
 50 1046 980 0.937 19.60 38.0 136.739 
40         
 0 0 0 0.000 0.00 38.0 N/A 
50         
 0 0 0 0.000 0.00 38.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1040 2322 2.233 46.44 26.0 464.163
Trend: 15.238        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/08/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 380 0.363 7.60 26.0 -10.169
Dimethyl Sulfoxide 
0         
 50 1043 421 0.404 8.42 26.0 0.000
Test Chemical Acrylonitrile 
1.6       
 50 1047 425 0.406 8.50 26.0 0.564 
5         
 50 1049 416 0.397 8.32 26.0 -1.753 
16         
 50 1049 411 0.392 8.22 26.0 -2.934 
50         
 50 1041 544 0.523 10.88 26.0 29.464 
160         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1042 1361 1.306 27.22 26.0 223.588
Trend: 3.497        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/18/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 407 0.391 8.14 26.0 0.000
Negative (Not Specified) 
0         
 50 1046 424 0.405 8.48 26.0 3.679
Test Chemical Acrylonitrile 
10         
 50 1036 438 0.423 8.76 28.0 8.136 
25         
 50 1038 513 0.494 10.26 28.0 26.409 
50         
 50 1027 620 0.604 12.40 28.0 54.411 
75         
 50 1047 850 0.812 17.00 28.0 107.648 
75         
 50 1046 788 0.753 15.76 38.0 92.686 
150         
 50 1040 1063 1.022 21.26 38.0 161.430
Positive Control Cyclophosphamide 
2         
 50 1050 1929 1.837 38.58 26.0 369.893
Trend: 21.333        
Probability: 0.000