Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01606-0014-0000-0 |
Chemical Name: | Acrylonitrile |
CASRN: | 107-13-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 189387 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 72 | 107 | 55 | 25 | 33 |
69 | 92 | 91 | 44 | ||||
85 | 105 | 58 | 23 | ||||
77 | 96 | 88 | 38 | ||||
Test Chemical | Acrylonitrile | 3.13 | 67 | 53 | 64 | 32 | 31 |
79 | 53 | 78 | 33 | ||||
62 | 69 | 53 | 28 | ||||
6.25 | 70 | 63 | 74 | 35 | 37 | ||
58 | 71 | 61 | 35 | ||||
52 | 68 | 65 | 41 | ||||
12.5 | 86 | 71 | 138 | 53 | 71* | ||
71 | 47 | 186 | 88 | ||||
25 | 79 | 31 | 346 | 147 | 212* | ||
72 | 31 | 337 | 156 | ||||
40 | 10 | 395 | 333 | ||||
50 | 46 | 3 | 588 | 428 | 414* | ||
34 | 3 | 491 | 479 | ||||
50# | 3 | 500 | 336 | ||||
100 | |||||||
Positive Control | Ethyl Methane Sulfonate | 250 | 49 | 50 | 684 | 462 | 449* |
49 | 42 | 686 | 464 | ||||
54 | 50 | 682 | 421 |
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 97 | 120 | 83 | 29 | 34 |
68# | 83 | 90 | 44 | ||||
78 | 97 | 69 | 30 | ||||
Test Chemical | Acrylonitrile | 0.005 | 45 | 51 | 35 | 26 | 24 |
69 | 66 | 45 | 22 | ||||
0.01 | 64# | 69 | 59 | 31 | 23 | ||
52 | 61 | 27 | 17 | ||||
84 | 71 | 52 | 21 | ||||
0.02 | 55 | 57 | 69 | 42 | 49 | ||
83 | 51 | 142 | 57 | ||||
64# | 56 | 95 | 49 | ||||
0.03 | 74 | 41 | 164 | 74 | 72* | ||
99# | 46 | 226 | 76 | ||||
78# | 46 | 155 | 67 | ||||
0.04 | 68# | 29 | 226 | 111 | 142* | ||
74 | 24 | 381 | 173 | ||||
0.05 | 53 | 7 | 365 | 230 | 192* | ||
88 | 22 | 407 | 155 | ||||
Positive Control | Methyl Methane Sulfonate | 10 | 26 | 6 | 447 | 562 | 562* |
Methyl Methane Sulfonate | 250 | 59 | 37 | 820 | 465 | 465* |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination