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Study Information
Study Attribute Value
CEBS Accession Number: 002-01617-0008-0000-5
Chemical Name: Aldicarb
CASRN: 116-06-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 145873
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 102 107 89 29 35
    95 100 91 32
    112 99 134 40
    101 94 113 37
Test Chemical Aldicarb 
1311         
 71 56 187 88 87*
    87 62 224 86
  
1638         
 103 65 276 89 88*
    91 59 239 88
  
2048         
 100 40 297 99 110*
    86 40 310 121
  
2560         
 75 34 265 118 111*
    82 45 255 104
  
3200         
 81 28 327 134 119*
    96 30 297 103
Positive Control Ethyl Methane Sulfonate 
500         
 35 17 802 775 676*
    46 30 852 613
    40 26 758 640

Nonactivation Trial: 2 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 63 104 56 29 25
    58 97 41 24
    58 106 48 27
    57 94 31 18
Test Chemical Aldicarb 
1476         
 67 103 47 23 32
    73 124 88 40
  
2952         
 62# 78 64 34 25
    72 72 36 17
  
3281         
 78 71 68 29 31
    85 74 83 32
  
3645         
 89 58 40 15 25
    78 53 80 34
  
4050         
 74 32 68 31 27
    49 14 34 23
  
4500         
 59 15 37 21 28
    40 8 43 36
  
5000         
   
Positive Control Ethyl Methane Sulfonate 
500         
 45 57 915 673 687*
    40 48 772 643
    38 41 838 745

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 70 97 72 34 35
    85 121 104 41
    73 110 71 32
    72 72 74 34
Test Chemical Aldicarb 
839         
 70 82 117 56 54*
    57 76 89 52
    65 87 107 55
  
1049         
 67 78 100 50 48
    72 74 120 56
    53 74 58 37
  
1311         
 75 81 142 63 58*
    68 65 107 53
  
1638         
 70 60 125 59 50
    65 55 74 38
    80 66 124 51
  
2048         
 71 51 129 61 53*
    87 58 97 37
    71 53 129 61
  
2560         
 70 35 144 69 74*
    68 33 168 82
    67 34 141 70
  
3200         
 59 12 156 88 95*
    67 13 167 83
    60 10 203 114
  
4000         
   
  
5000         
   
   
Positive Control Ethyl Methane Sulfonate 
500         
 57 55 882 520 489*
    56 51 765 457

Induced S9 Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 102 104 185 60 58
    95 107 142 50
    88# 91 151 57
    90# 97 171 63
Test Chemical Aldicarb 
1049         
 93 99 196 71 66
    111 114 203 61
  
1310         
 85# 87 192 75 66
    117# 120 199 56
  
1638         
 105 103 227 72 86
    86 84 259 100
  
2048         
 108 105 225 69 70
    108 100 229 71
  
2560         
 91 81 249 91 90*
    81 72 213 88
  
3200         
 88# 76 267 101 102*
    91 81 282 104
  
4000         
 87 61 301 116 132*
    84 48 371 148
Positive Control 3-Methylcholanthrene 
5         
 73 59 673 306 289*
    80 65 662 275
    80 61 685 285

Induced S9 Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 113# 113 150 44 42
    98 100 109 37
    89 90 102 38
    100 97 146 49
Test Chemical Aldicarb 
1048         
 116 75 240 69 60
    115 80 176 51
  
1310         
 110 90 169 51 53
    116 83 193 55
  
1638         
 111 80 240 72
  
2048         
 109 82 150 46 48
    107 81 159 49
  
2560         
 89 80 163 61 61
    109 83 196 60
  
3200         
 103 84 144 46 69*
    94 76 254 91
  
4000         
 102 68 307 100 91*
    91 56 222 82
Positive Control 3-Methylcholanthrene 
5         
 55 33 633 381 354*
    76# 38 738 323
    71 32 764 359

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination