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Study Information
Study Attribute Value
CEBS Accession Number: 002-01618-0001-0000-9
Chemical Name: Aldicarb oxime
CASRN: 1646-75-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 664050_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/12/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 445 0.427 8.90 26.5 0.000
Test Chemical Aldicarb oxime 
49.7       
 50 1048 441 0.421 8.82 26.5 -1.561 
149         
 50 1046 445 0.425 8.90 26.5 -0.478 
497         
 50 1048 518 0.494 10.36 30.5 15.627 
1490         
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1045 590 0.565 11.80 26.5 32.077
Mitomycin-C 
 0.01      
 10 211 196 0.929 19.60 26.5 117.302
Trend: 2.265        
Probability: 0.012        

Trial #: 2    Activation: No Activation    Date: 12/03/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 481 0.461 9.62 26.5 0.000
Test Chemical Aldicarb oxime 
148         
 50 1045 513 0.491 10.26 26.5 6.449 
297         
 50 1045 562 0.538 11.24 26.5 16.616 
395         
 50 1040 549 0.528 10.98 26.5 14.466 
493         
 50 1042 601 0.577 12.02 30.5 25.068 
590         
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1049 614 0.585 12.28 26.5 26.921
Mitomycin-C 
 0.01      
 10 210 258 1.229 25.80 26.5 166.403
Trend: 3.803        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/12/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 483 0.460 9.66 26.0 0.000
Test Chemical Aldicarb oxime 
149         
 50 1048 472 0.450 9.44 26.0 -1.998 
497         
 50 1051 543 0.517 10.86 26.0 12.422 
1490         
 50 1049 534 0.509 10.68 26.0 10.770 
4970         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1046 1023 0.978 20.46 26.0 112.814
Cyclophosphamide 
2.5       
 10 212 465 2.193 46.50 26.0 377.279
Trend: 2.255        
Probability: 0.012