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Study Information
Study Attribute Value
CEBS Accession Number: 002-01618-0002-0000-0
Chemical Name: Aldicarb oxime
CASRN: 1646-75-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 664050_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 11/21/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: Aldicarb oxime 
301         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
1000         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
3010         
 200 13 0.065 6.0 0 0.000 0.0 12 0.060 5.5 1 0.005 1.0 
5010         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 100 27 0.270 22.0 14 0.140 13.0 12 0.120 12.0 1 0.010 1.0
Mitomycin-C 
5         
 50 26 0.520 40.0 11 0.220 22.0 15 0.300 26.0 0 0.000 0.0
Trend: 2.677 -1.292 2.810  
Probability: 0.004 0.902 0.002  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/21/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 6 0.030 3.0 4 0.020 4.0 2 0.010 2.0 0 0.000 0.0
Test Chemical: Aldicarb oxime 
151         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
500         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1510         
 200 10 0.050 4.0 0 0.000 0.0 10 0.050 4.0 0 0.000 0.0 
3010         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 36 0.720 44.0 21 0.420 32.0 15 0.300 20.0 0 0.000 0.0
Trend: 0.356 -3.675 1.232  
Probability: 0.361 1.000 0.109