COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01618-0003-0000-1
Chemical Name: Aldicarb oxime
CASRN: 1646-75-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 679323_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/14/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 415 0.398 8.30 26.0 0.000
Test Chemical Aldicarb oxime 
16         
 50 1043 388 0.372 7.76 26.0 -6.416 
50         
 50 1051 428 0.407 8.56 26.0 2.446 
160         
 50 1046 445 0.425 8.90 26.0 7.024 
500         
 50 1042 466 0.447 9.32 26.0 12.505 
1600         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1042 572 0.549 11.44 26.0 38.096
Mitomycin-C 
 0.005     
 10 210 328 1.562 32.80 26.0 292.923
Trend: 2.437        
Probability: 0.007        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/14/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 441 0.422 8.82 26.0 0.000
Test Chemical Aldicarb oxime 
50         
 50 1048 506 0.483 10.12 26.0 14.411 
160         
 50 1048 527 0.503 10.54 26.0 19.159 
500         
 50 1043 529 0.507 10.58 26.0 20.185 
1600         
 50 1047 531 0.507 10.62 26.0 20.178
Positive Control Cyclophosphamide 
 0.1       
 50 1047 625 0.597 12.50 26.0 41.453
Cyclophosphamide 
 0.6       
 10 209 205 0.981 20.50 26.0 132.426
Trend: 2.860        
Probability: 0.002        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/24/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1050 449 0.428 8.98 26.0 0.000
Test Chemical Aldicarb oxime 
50         
 50 1049 528 0.503 10.56 26.0 17.707 
160         
 50 1050 507 0.483 10.14 26.0 12.918 
500         
 50 1050 537 0.511 10.74 26.0 19.599 
1600         
 50 1050 518 0.493 10.36 26.0 15.367
Positive Control Cyclophosphamide 
 0.1       
 50 1050 733 0.698 14.66 26.0 63.252
Cyclophosphamide 
 0.6       
 10 210 278 1.324 27.80 26.0 209.577
Trend: 2.054        
Probability: 0.020