Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01618-0003-0000-1 |
Chemical Name: | Aldicarb oxime |
CASRN: | 1646-75-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 679323_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Positive |
Induced Rat Liver S9 | 2_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1044 | 415 | 0.398 | 8.30 | 26.0 | 0.000 |
Test Chemical | Aldicarb oxime | 16 | 50 | 1043 | 388 | 0.372 | 7.76 | 26.0 | -6.416 |
50 | 50 | 1051 | 428 | 0.407 | 8.56 | 26.0 | 2.446 | ||
160 | 50 | 1046 | 445 | 0.425 | 8.90 | 26.0 | 7.024 | ||
500 | 50 | 1042 | 466 | 0.447 | 9.32 | 26.0 | 12.505 | ||
1600 | 0 | 0 | 0 | 0.000 | 0.00 | 26.0 | N/A | ||
Positive Control | Mitomycin-C | 0.0E-4 | 50 | 1042 | 572 | 0.549 | 11.44 | 26.0 | 38.096 |
Mitomycin-C | 0.005 | 10 | 210 | 328 | 1.562 | 32.80 | 26.0 | 292.923 | |
Trend: | 2.437 | ||||||||
Probability: | 0.007 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1045 | 441 | 0.422 | 8.82 | 26.0 | 0.000 |
Test Chemical | Aldicarb oxime | 50 | 50 | 1048 | 506 | 0.483 | 10.12 | 26.0 | 14.411 |
160 | 50 | 1048 | 527 | 0.503 | 10.54 | 26.0 | 19.159 | ||
500 | 50 | 1043 | 529 | 0.507 | 10.58 | 26.0 | 20.185 | ||
1600 | 50 | 1047 | 531 | 0.507 | 10.62 | 26.0 | 20.178 | ||
Positive Control | Cyclophosphamide | 0.1 | 50 | 1047 | 625 | 0.597 | 12.50 | 26.0 | 41.453 |
Cyclophosphamide | 0.6 | 10 | 209 | 205 | 0.981 | 20.50 | 26.0 | 132.426 | |
Trend: | 2.860 | ||||||||
Probability: | 0.002 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Medium | 0 | 50 | 1050 | 449 | 0.428 | 8.98 | 26.0 | 0.000 |
Test Chemical | Aldicarb oxime | 50 | 50 | 1049 | 528 | 0.503 | 10.56 | 26.0 | 17.707 |
160 | 50 | 1050 | 507 | 0.483 | 10.14 | 26.0 | 12.918 | ||
500 | 50 | 1050 | 537 | 0.511 | 10.74 | 26.0 | 19.599 | ||
1600 | 50 | 1050 | 518 | 0.493 | 10.36 | 26.0 | 15.367 | ||
Positive Control | Cyclophosphamide | 0.1 | 50 | 1050 | 733 | 0.698 | 14.66 | 26.0 | 63.252 |
Cyclophosphamide | 0.6 | 10 | 210 | 278 | 1.324 | 27.80 | 26.0 | 209.577 | |
Trend: | 2.054 | ||||||||
Probability: | 0.020 |