Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01618-0004-0000-2 |
Chemical Name: | Aldicarb oxime |
CASRN: | 1646-75-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 679323_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Aldicarb oxime | 500 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
1000 | 200 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | ||
1600 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 53 | 0.265 | 23.5 | 22 | 0.110 | 10.5 | 31 | 0.155 | 14.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 22 | 0.440 | 36.0 | 7 | 0.140 | 14.0 | 15 | 0.300 | 28.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.683 | 0.000 | -0.683 | ||||||||||||
Probability: | 0.753 | 0.000 | 0.753 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Aldicarb oxime | 500 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
1000 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
1600 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 43 | 0.215 | 19.0 | 12 | 0.060 | 5.0 | 31 | 0.155 | 14.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 26 | 0.520 | 48.0 | 11 | 0.220 | 20.0 | 15 | 0.300 | 30.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.813 | 1.272 | 0.462 | ||||||||||||
Probability: | 0.208 | 0.102 | 0.322 |