COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01624-0001-0000-6
Chemical Name: Alloxan monohydrate
CASRN: 3237-50-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 360113_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 
Induced Rat Liver S9  3_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 11/27/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 448 0.427 8.96 26.5 0.000
Test Chemical Alloxan monohydrate 
89.7       
 50 1047 466 0.445 9.32 26.5 4.217 
299         
 50 1041 460 0.442 9.20 26.5 3.468 
897         
 50 1051 468 0.445 9.36 26.5 4.265
Positive Control Mitomycin-C 
 0.002     
 50 1048 800 0.763 16.00 26.5 78.742
Mitomycin-C 
 0.01      
 10 211 333 1.578 33.30 26.5 269.538
Trend: 0.561        
Probability: 0.287        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/27/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1041 499 0.479 9.98 26.0 0.000
Test Chemical Alloxan monohydrate 
299         
 50 1047 520 0.497 10.40 26.0 3.611 
897         
 50 1048 582 0.555 11.64 26.0 15.854 
2990         
 50 1045 715 0.684 14.30 26.0 42.738
Positive Control Cyclophosphamide 
 0.5       
 50 1047 751 0.717 15.02 26.0 49.639
Cyclophosphamide 
2.5       
 10 209 341 1.632 34.10 26.0 240.375
Trend: 6.564        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/13/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 451 0.430 9.02 25.5 0.000
Test Chemical Alloxan monohydrate 
2000         
 50 1051 509 0.484 10.18 25.5 12.753 
2500         
 50 1048 552 0.527 11.04 25.5 22.628 
3000         
 50 1050 537 0.511 10.74 25.5 19.069
Positive Control Cyclophosphamide 
 0.5       
 50 1043 873 0.837 17.46 25.5 94.869
Cyclophosphamide 
2.5       
 10 211 412 1.953 41.20 25.5 354.598
Trend: 3.036        
Probability: 0.001        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 01/03/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 394 0.377 7.88 25.5 0.000
Test Chemical Alloxan monohydrate 
1990         
 50 1042 430 0.413 8.60 25.5 9.556 
2490         
 50 1047 475 0.454 9.50 25.5 20.443 
2990         
 50 1048 504 0.481 10.08 25.5 27.675
Positive Control Cyclophosphamide 
 0.5       
 50 1045 567 0.543 11.34 25.5 44.046
Cyclophosphamide 
2.5       
 10 209 284 1.359 28.40 25.5 260.751
Trend: 3.906        
Probability: 0.000