Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01624-0002-0000-7 |
Chemical Name: | Alloxan monohydrate |
CASRN: | 3237-50-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 360113_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 8 | 0.080 | 5.0 | 2 | 0.020 | 2.0 | 6 | 0.060 | 4.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Alloxan monohydrate | 300 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
1000 | 100 | 5 | 0.050 | 4.0 | 0 | 0.000 | 0.0 | 5 | 0.050 | 4.0 | 0 | 0.000 | 0.0 | ||
3000 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 5 | 50 | 37 | 0.740 | 44.0 | 21 | 0.420 | 28.0 | 16 | 0.320 | 24.0 | 0 | 0.000 | 0.0 |
Trend: | -0.963 | -1.823 | -0.510 | ||||||||||||
Probability: | 0.832 | 0.966 | 0.695 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Alloxan monohydrate | 300 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
1000 | 100 | 4 | 0.040 | 2.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 1.0 | 0 | 0.000 | 0.0 | ||
3000 | 100 | 2 | 0.020 | 1.0 | 2 | 0.020 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 36 | 0.720 | 40.0 | 17 | 0.340 | 28.0 | 19 | 0.380 | 28.0 | 0 | 0.000 | 0.0 |
Trend: | 1.319 | 1.277 | 0.476 | ||||||||||||
Probability: | 0.094 | 0.101 | 0.317 |