COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01632-0001-0000-5
Chemical Name: Allyl glycidyl ether
CASRN: 106-92-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 691488_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/24/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1017 423 0.416 8.46 25.5 0.000
Test Chemical Allyl glycidyl ether 
1         
 50 1026 763 0.744 15.26 25.5 78.796 
3.3       
 50 1033 921 0.892 18.42 25.5 114.358 
10         
 50 1028 1238 1.204 24.76 25.5 189.540 
33.4       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1033 737 0.713 14.74 25.5 71.533
Mitomycin-C 
 0.01      
 5 102 198 1.941 39.60 25.5 366.708
Trend: 19.877        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/13/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 20 406 177 0.436 8.85 25.6 0.000
Test Chemical Allyl glycidyl ether 
30         
 20 405 586 1.447 29.30 25.6 231.891 
39.8       
 20 416 838 2.014 41.90 34.0 362.065 
50.2       
 20 416 932 2.240 46.60 34.0 413.896 
76         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 20 408 282 0.691 14.10 25.6 58.541
Mitomycin-C 
 0.01      
 5 98 188 1.918 37.60 25.6 340.032
Trend: 22.155        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/24/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 598 0.579 11.96 25.5 0.000
Test Chemical Allyl glycidyl ether 
3.3       
 50 1043 777 0.745 15.54 25.5 28.563 
10         
 50 1023 772 0.755 15.44 25.5 30.233 
33.4       
 50 1032 1010 0.979 20.20 33.3 68.896 
100.1       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1030 943 0.916 18.86 25.5 57.999
Cyclophosphamide 
2         
 5 104 189 1.817 37.80 25.5 213.622
Trend: 9.968        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/13/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 20 415 249 0.600 12.45 25.6 0.000
Test Chemical Allyl glycidyl ether 
60         
 20 413 367 0.889 18.35 34.0 48.103 
79.5       
 20 419 443 1.057 22.15 34.0 76.213 
100         
 20 414 465 1.123 23.25 34.0 87.198 
150         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 20 415 466 1.123 23.30 25.6 87.149
Cyclophosphamide 
2         
 5 106 249 2.349 49.80 25.6 291.509
Trend: 8.398        
Probability: 0.000