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Study Information
Study Attribute Value
CEBS Accession Number: 002-01632-0001-0000-5
Chemical Name: Allyl glycidyl ether
CASRN: 106-92-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 691488_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/24/1984    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1017 423 0.416 8.46 25.5 0.000
Test Chemical Allyl glycidyl ether
1         
50 1026 763 0.744 15.26 25.5 78.796
3.3       
50 1033 921 0.892 18.42 25.5 114.358
10         
50 1028 1238 1.204 24.76 25.5 189.540
33.4       
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.0015    
50 1033 737 0.713 14.74 25.5 71.533
Mitomycin-C
 0.01      
5 102 198 1.941 39.60 25.5 366.708
Trend: 19.877        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/13/1984    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
20 406 177 0.436 8.85 25.6 0.000
Test Chemical Allyl glycidyl ether
30         
20 405 586 1.447 29.30 25.6 231.891
39.8       
20 416 838 2.014 41.90 34.0 362.065
50.2       
20 416 932 2.240 46.60 34.0 413.896
76         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.0015    
20 408 282 0.691 14.10 25.6 58.541
Mitomycin-C
 0.01      
5 98 188 1.918 37.60 25.6 340.032
Trend: 22.155        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/24/1984    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1032 598 0.579 11.96 25.5 0.000
Test Chemical Allyl glycidyl ether
3.3       
50 1043 777 0.745 15.54 25.5 28.563
10         
50 1023 772 0.755 15.44 25.5 30.233
33.4       
50 1032 1010 0.979 20.20 33.3 68.896
100.1       
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.4       
50 1030 943 0.916 18.86 25.5 57.999
Cyclophosphamide
2         
5 104 189 1.817 37.80 25.5 213.622
Trend: 9.968        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/13/1984    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
20 415 249 0.600 12.45 25.6 0.000
Test Chemical Allyl glycidyl ether
60         
20 413 367 0.889 18.35 34.0 48.103
79.5       
20 419 443 1.057 22.15 34.0 76.213
100         
20 414 465 1.123 23.25 34.0 87.198
150         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.4       
20 415 466 1.123 23.30 25.6 87.149
Cyclophosphamide
2         
5 106 249 2.349 49.80 25.6 291.509
Trend: 8.398        
Probability: 0.000